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Full-time
Bioinformatics Research Officer Job at Infectious Diseases Institute (IDI)
Infectious Diseases Institute (IDI)
Job Description
The Bioinformatics Research Officer will provide advanced technical and analytical support for the computational components of the Combating Antimalarial Resistance: An AI-Driven Approach to Identify and Prioritize Key Parasite Mutations (AIMaR) project.
This position is ideally suited for a candidate who possesses strong bioinformatics skills combined with deep knowledge of malaria biology and Plasmodium falciparum. The successful candidate will leverage computational approaches to address critical malaria research questions, particularly those related to antimalarial drug resistance and immune evasion mechanisms. This role involves implementing bioinformatics pipelines, conducting genomic analyses, supporting AI model implementation, and managing computational workflows on HPC systems. The position offers substantial opportunity for skill development, co-authorship on publications, and hands-on experience with advanced computational methods including EVE and AlphaFold 3.
Duties, Roles and Responsibilities
- Implement and execute standardized pipelines for preprocessing P. falciparum genomic data
- Conduct quality control of raw sequence data using FastQC, Trimmomatic, and related tools
- Perform sequence alignment using BWA-MEM and variant calling using established protocols
- Apply filtering criteria to ensure high-quality variant datasets (depth, quality scores, mapping quality)
- Harmonize metadata across multiple datasets, including clinical and epidemiological variables
- Conduct GWAS analysis
- Generate comprehensive QC reports documenting data processing steps and outcomes
- Support validation of EVE predictions against experimentally confirmed variations, interpreting results in the context of parasite biology
- Troubleshoot pipeline failures and optimize computational workflows for efficiency
- Maintain version control and documentation for all analysis scripts
- Apply understanding of P. falciparum biology to inform quality control decisions and identify biologically relevant variants
- Participate in regular project meetings and present analytical findings with clear connections to malaria biology
- Collaborate with structural biologists and laboratory scientists, bridging computational and wet-lab perspectives
- Contribute to manuscript preparation, including methods sections, results interpretation, and supplementary materials
- Assist in preparing figures and tables for publications and presentations
- Support training activities for junior staff and research assistants
- Document technical procedures that will be included in the project report.
- Translate complex bioinformatics results into insights accessible to malaria researchers and public health practitioners
Qualifications, Education and Competencies
See all details of the qualifications, competencies and education for this role under the "How to Apply" section below.
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